MOTS-C
- ≥99% purity by HPLC
- Janoshik COA with every lot
- Lot-traceable from synthesis
- EU-synthesised
Specifications
Third Party Lab Tested
Every lot is independently HPLC-tested by Janoshik Analytical, Europe's reference laboratory for peptide purity assessment. The COA shipped with your order is theirs, not ours.
Storage & Handling
Lyophilized peptides should be stored below 16°C, protected from light and moisture, for up to 24 months. Once reconstituted, refrigerate and use within 30 days for protocol consistency.
Reconstitution
Reconstitute with bacteriostatic water using the volumes below. Add solvent slowly along the inside wall of the vial. Swirl gently, never shake, until fully dissolved.
Lab-handling protocol BAC Water · 0.9% benzyl alcohol The reconstitution solvent referenced above. Add to order →The mitochondrial
signaling peptide.
MOTS-c is one of the first identified mitochondrial-derived peptides - encoded within the mitochondrial 12S rRNA gene rather than the nuclear genome. Its function in research models is to signal back to the nucleus and regulate metabolic homeostasis, making it structurally distinct from any classical signaling peptide.
Its citation profile in metabolic-aging and exercise-physiology research is rapidly expanding. For protocols studying mito-nuclear communication or AMPK pathway modulation, this is the canonical reference compound.
| Compound | MOTS-c |
|---|---|
| Sequence length | 16 amino acids |
| Molecular mass | 1761.0 Da |
| Mechanism / research class | Mitochondrial-derived peptide. AMPK pathway activator. |
| Lab handling solvent | 2mL bacteriostatic water for injection (BWI) |
| Resulting concentration | Yields 0.5mg per 0.1mL |
| Supply format | 10MG · Mitochondrial-derived lyophilized research vial |
| Storage, lyophilized | store below 16°C for up to 24 months |
| Storage, reconstituted | refrigerate and use within 30 days |
Synthesised.
Verified.
Documented.
Backed by research.
Measured in results.
Each tag opens the cited literature behind that effect. References are linked to PubMed.
MOTS-c is one of the first identified mitochondrially-derived peptides (MDPs). It activates AMPK and modulates downstream metabolic-flexibility endpoints in research models - uniquely encoded inside mitochondrial DNA itself rather than the nuclear genome.
- Lee C et al. The mitochondrial-derived peptide MOTS-c regulates metabolic homeostasis. Cell Metab. 2015;21(3):443-454. PubMed ↗
Exogenous MOTS-c administration produces measurable improvements in insulin sensitivity and glucose homeostasis markers in animal models of metabolic aging.
- Reynolds JC et al. MOTS-c is an exercise-induced mitochondrial-encoded regulator. Nat Commun. 2021;12:470. PubMed ↗
Questions?
We got answers.
Show references
Used in published research.
4.6 / 5
Solid product, fast EU shipping
Ordered MOTS-C for a research-protocol pilot. Arrived in 4 days temperature-controlled, vials sealed and properly lyophilized. Reconstituted cleanly in BWI with no haze. Will reorder.
